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Innovative strategies, including phage therapy, live biotherapeutics, precision nutrition, and microbiota transplantation, demonstrate the therapeutic potential of utilizing microbial functions to prevent or treat diseases. However, interindividual variability in microbiome composition, driven by diet, geography, host genetics, antibiotic exposure, and age, remains a key barrier to reproducibility and complicates the development of universally applicable diagnostic and therapeutic tools.
Bautista et al. 2025 Front M…