Epithelial Barrier Integrity / Mucosal Barrier Integrity & Gut microbiota

The microbiota produces factors that improve tight junctions within epithelia, increase mucus production, stimulate wound healing, and increase stem cell proliferation.

Reduced barrier function leads to leakage of microbial organisms or their products, which can gain access to systemic sites and alter the inflammatory environment
Zheng et al. 2020c Cell Res. 30: 492-506

PGE2 and PGI2 have a synergistic role in restoration of intestinal barrier function by increasing intracellular cAMP and Ca2+, respecti…