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A primary event that elicits NFKB activation in mammalian B cells is antigen recognition through B cell receptors (BCRs) . Once engaged, the receptors induce the interaction of CARMA1 with a pre- assembled dimer of mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1) and B cell lymphoma 10 (BCL10) following its phosphorylation by Protein kinase C beta type (in B cells)
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