meRfi®-GM
Intestinal immune system
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Contents
Recent discoveries have identified the presence of memory T cells in various fetal tissues, including the intestines of both human and nonhuman primates (; ; ; ; ), cord blood (), and the placenta ().
These findings suggest that the education of the intestinal adaptive immune system may begin in utero. This implies that the critical period for shaping intestinal homeostasis could start before birth
Koren et al. 2024 Nat Rev Gas…
References (Sources)
- Gut immune microenvironment and autoimmunity
- Human fetal TNF-alpha-cytokine-producing CD4(+) effector memory T cells promote intestinal development and mediate inflammation early in life
- Intestinal cell type-specific communication networks underlie homeostasis and response to Western diet
- Intraepithelial lymphocytes of the intestine
- Memory CD4(+) T cells are generated in the human fetal intestine
- Microbial exposure during early human development primes fetal immune cells
- Ontogeny of FOXP3 +regulatory T cells in the postnatal human small intestinal and large intestinal lamina propria