meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Gut barrier dysfunction
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Contents
Gut Barrier Dysfunction and Microbial-mediated Systemic Inflammation – in Conjunction with Unfavorable Host Genetics – Can Lead to Malignant Transformation, Here, in the Context of Myeloid Cancer
Small-intestinal barrier dysfunction leads to bacterial translocation and to high levels of IL-6.
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References (Sources)
- Gut Barrier Dysfunction-a Primary Defect in Twins With Crohn’s Disease Predominantly Caused by Genetic Predisposition
- Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
- Systemic Immunoregulatory Consequences of Gut Commensal Translocation
- The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats
- The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression