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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Lacticaseibacillus casei Shirota

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There have been several reports of the ability of a fermented milk containing Lactobacillus casei strain Shirota (LcS) to prevent infectious disease and modulate immune function (e.g., natural killer cell activity)
Takeda et al 2006 Clin Exp Immunol 146: 109-115
Nagata et al. 2011 Br J Nutr 106: 549-556
Dong et al. 2013 Eur J Nutr 52: 1853–1863
Fujita et al. 2013 Am J Infect Control 41: 1231-1235
Nagata et al. 2016 Ann Nutr Metab 68: 51-59

Consumption of a probiotic drink containing Lactobacillus casei Shirota for 4 weeks by the elderly was reported to improve the tumoricidal activity of natural killer (NK) cells, increase the serum level of interleukin (IL)-10
(Dong et al. 2013 Eur J Nutr 52: 1853–1863), and reduce the number of days on which fever was detected
Kushiro et al., 2019

…

References (Sources)

Decreased duration of acute upper respiratory tract infections with daily intake of fermented milk: a multicenter, double-blinded, randomized comparative study in users of day care facilities for the elderly population
Fujita et al. 2013 Am J Infect Control 41: 1231-1235
Decreased number of days of fever detection and duration of fever with continuous intake of a fermented milk drink: a randomized, double-blind, placebo-controlled study of elderly nursing home residents.
Kushiro et al. 2019 Biosci Microbiota Food Health 38: 151-157
Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged
Nagata et al. 2011 Br J Nutr 106: 549-556
Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers.
Dong et al. 2013 Eur J Nutr 52: 1853–1863
Interleukin-12 is involved in the enhancement of human natural killer cell activity by Lactobacillus casei Shirota
Takeda et al 2006 Clin Exp Immunol 146: 109-115
Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models
Takada et al. 2016 Neurogastroenterol. Motil. 28(7): 1027-1036
The effectiveness of Lactobacillus beverages in controlling infections among the residents of an aged care facility: a randomized placebo-controlled double-blind trial
Nagata et al. 2016 Ann Nutr Metab 68: 51-59

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