Lacticaseibacillus casei Shirota

There have been several reports of the ability of a fermented milk containing Lactobacillus casei strain Shirota (LcS) to prevent infectious disease and modulate immune function (e.g., natural killer cell activity)
Takeda et al 2006 Clin Exp Immunol 146: 109-115
Nagata et al. 2011 Br J Nutr 106: 549-556
Dong et al. 2013 Eur J Nutr 52: 1853–1863
Fujita et al. 2013 Am J Infect Control 41: 1231-1235
Nagata et al. 2016 Ann Nutr Metab 68: 51-59

Consumption of a probiotic drink containing Lactobacillus casei Shirota for 4 weeks by the elderly was reported to improve the tumoricidal activity of natural killer (NK) cells, increase the serum level of interleukin (IL)-10
(Dong et al. 2013 Eur J Nutr 52: 1853–1863), and reduce the number of days on which fever was detected
Kushiro et al., 2019