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Gut microbiota & Irritable Bowel Syndrome (IBS)
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Contents
Altered diet, aberrant usage of antibiotics, or exposure to severe enterocolitis induce gut dysbiosis, resulting in mucosal immune activation and low-grade inflammation, as well as gut barrier dysfunction through increased epithelial permeability. These pathways, along with psychological factors, influence the gut-brain-microbiome axis, mediated by pathways and psychological factors that influence the microbiota-gut-brain axis, which is mediated by aberrant neuroendocrine factors, transmitters, and metabolites, resulting in altered gut motility and visceral hypersensitivity. The chronic status of such gut dysfunctions shapes IBS symptoms, including abnormal bowel movements and visceral pain
The clinical guidance regarding modulation of gut microbiota in Irritable Bowel Syndrome (IBS) p…
References (Sources)
- Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome
- Gut microbiota in patients with irritable bowel syndrome-A systematic review
- Intestinal microbiota in functional bowel disorders: a Rome foundation report
- Microbiome and Gut Dysbiosis
- Prebiotics in IBS and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled trials
- Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in IBS
- The gut-brain axis and the microbiome: clues to pathophysiology and opportunities for novel management strategies in irritable bowel syndrome (IBS)