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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Cyclin-dependent kinase inhibitor 1 (p21Cip1/Waf1)

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Contents

Cyclin-dependent kinase inhibitor 1 (p21Cip1/Waf1) is a well-established endogenous CDK inhibitor for particularly Cyclin-dependent kinase 2 (CDK2), Cyclin-dependent kinase 1 (CDK1), Cyclin-dependent kinase 4 (CDK4), and Cyclin-dependent kinase 6 (CDK6) and can act as a tumor suppressor.

Fredersdorf et al. 1996 Am J Pathol 148(3): 825-35
Kriwacki et al. 1996 Proc Natl Acad Sci USA 93(21): 11504-9
Hengst et al. 1998 Genes Dev 12(24): 3882-8
El-Deiry 20…

References (Sources)

CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication
Mansilla et al. 2020 Genes 11: 593
Review
CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?
Manousakis et al. 2023 Int J Mol Sci 24(24): 17488
Review
Characterization of a panel of novel anti-p21Waf1/Cip1 monoclonal antibodies and immunochemical analysis of p21Waf1/Cip1 expression in normal human tissues
Fredersdorf et al. 1996 Am J Pathol 148(3): 825-35
Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1)
Hengst et al. 1998 Genes Dev 12(24): 3882-8
Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity
Kriwacki et al. 1996 Proc Natl Acad Sci USA 93(21): 11504-9
The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
Kreis et al. 2019 Cancers (Basel) 11(9): 1220
Review
The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics
Al Bitar & Gali-Muhtasib 2019 Cancers (Basel) 11(10):1475
Review

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