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Bile acids can be harmful to the liver. When they build up in liver cells, they mainly bind to a receptor called Farnesoid X receptor (FXR / NR1H4), and to a lesser extent, to the Pregnane-X Receptor (PXR) and to the Constitutive androstane receptor (CAR). In mice, these receptors help reduce the production of bile acids by turning off certain enzymes, like [Cholesterol 7 alfa-hydroxylase (CYP7A1)](brain://OVD7UFaInUGsBbdALohMkw/…