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Formyl peptides released by all bacteria bind formyl peptide receptors (FPRs), which are G-protein coupled receptors (GPCRs) that are found on neutrophils and other immune cells. Formyl peptides from Staphylococcus aureus can signal through Formyl peptide receptor 1 (FPR1) and contribute to the activation of nociceptor-driven mechanical pain and the release of immunosuppressive neuropeptides. At high nanomolar concentrations, [Staphylococcus aureus](brain://…