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Interleukin-23 (IL-23)
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Contents
Interleukin-23 (IL-23) is an inflammatory cytokine that is key for the maintenance and expansion of T helper 17 cell.
It is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit and an IL-23-specific subunit, Interleukin 23 subunit alfa
Monoclonal antibodies such as Guselkumab, Risankizumab, Tildrakizumab, Mirikizumab, and Ustekinumab have been developed to inhibit [Interleukin-23 (IL-23)](brain://u5wmCBhh3la…
References (Sources)
- IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
- IL-33 Coordinates Innate Defense to Systemic Candida albicans Infection by Regulating IL-23 and IL-10 in an Opposite Way
- Interleukin-12 and – 23 Control plasticity of CD127(+) group 1 and group 3 innate lymphoid cells in the intestinal lamina propria
- Interleukin-17 and type 17 helper T cells
- Th17 cell induction by adhesion of microbes to intestinal epithelial cells