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Butyrate / Butyric acid is a direct, potent inhibitor of histone deacetylases (HDACs), particularly [Histone Deacetylases (HDACs) Class I], Histone Deacetylases (HDACs) Class IIA(brain://bnGv9eMIyEGBlLav_1EhOg/HistoneDeacetylasesHDACsClassI) and Histone Deacetylases (HDACs) Class IIB, leading to increased acetylation of histone proteins, chromatin relaxation, and altered transcription of genes (upregulation or downregulation of many genes) involved in immune homeostasis, inflammat…