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The lectin complement pathway is initiated by Mannose-binding lectin (MBL) and ficolins that bind to particular carbohydate structures on microbial surfaces.
Lectin pathway: Requires carbohydrates on pathogen surfaces
Lectin Pathway: Activated MASP-2 cleaves C4 & C2 to C4a, C4b, C2a, C2b
Lectin Pathway: Generation of C3-convertase (C4b2a)
Lectin Pathway: C3-convertase cleaves & activates C3 to C3a & C3b
Lectin pathway: C3b binds covalently to the microbial surface & acts as an opsonin
Lectin pathway: C3b also binds to C3 convertase to form C5 convertase (C3b2Bb)
Lectin Pathway: C5-convertase cleaves C5 to C5a (11 kDa) und C5b (190 kDa)
Lectin Pat…