meRfi®-GM
Colorectal Cancer (CRC) & Fusobacterium nucleatum
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
Tumor-isolated strains mainly belong to Fusobacterium nucleatum animalis. Fusobacterium nucleatum animalis is divided into two clades: Fna C1 and Fna C2. Fna C2 is predominant in the Colorectal Cancer (CRC) environment. 195 genetic factors associated with Fna C2 suggest increased metabolic potential and gastrointestinal colonization. Fna C2-treated mice showed more intestinal adenomas and altered metabolites. Human tumor tissue analysis from 116 CRC patients showed Fna C2 enrichment. The study identifies the bifurcation of the Fna clade, highlights Fna C2's role in Fusobacterium nucleatum enrichment in CRC, and uncovers genetic factors …
References (Sources)
- Colon cancer-associated Fusobacterium nucleatum may originate from the oral cavity and reach colon tumors via the circulatory system
- Comparative analysis of colon cancer-derived Fusobacterium nucleatum subspecies: inflammation and colon tumorigenesis in murine models
- Expanding the genetic toolkit helps dissect a global stress response in the early-branching species Fusobacterium nucleatum
- Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
- Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer
- Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating KRT7-AS/KRT7
- Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15