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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Activation / Activators & Macrophages

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Macrophage activation was closely related to glucose metabolism
Li et al. 2022k J Immunol 208(10): 2309-2318

Macrophage activation increases intracellular succinate, stabilizing the transcription factor hypoxia-inducible factor (HIF)-1alfa which speciﬁcally results in elevated Il1b expression
Olona et al. 2022 Trends in Immunology 43(12): 978

TRPM7 is a non-selective Ca2+ ion channel. This increases cytosolic Ca2+, which is essential for [Lipopolysaccharides (LPS)](brain://d90CNw3UskWbP8YLwO7igA/L…

References (Sources)

Alternative activation of macrophages
Gordon 2003 Nat. Rev. Immunol. 3: 23-35
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez et al. 2009 Annu. Rev. Immunol. 27: 451-483
Review
Berberine Modulates Macrophage Activation by Inducing Glycolysis
Li et al. 2022k J Immunol 208(10): 2309-2318
Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation
Schappe et al. 2018 Immunity 48: 59-74
Supramolecular Assemblies for Macrophage Activation in Cancer Therapy
Mejia et al. 2018 Trends in Cancer 4: 713
The NLRP3 inflammasome: regulation by metabolic signals
Olona et al. 2022 Trends in Immunology 43(12): 978

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