Growth/differentiation factor 15 (GDF15)

Growth differentiation factor 15 (GDF-15) is a cytokine widely used as a biomarker for the severity of diverse disease states
Reyes et al. 2023 J Immunol 210(1): 5-11

It also has been shown to play a protective role after tissue injury and to promote a negative energy balance during obesity and diabetes
Reyes et al. 2023 J Immunol 210(1): 5-11

GDF15 is a pleiotropic protein with metabolic, feeding, and immunomodulatory effects
Sarkar et al. 2022 Expert Opinion on Therapeutic Targets 26(1): 57-67