Secreted Immunoglobulin A (sIgA) / IgA

IgA, the primary secreted antibody, accumulates mutations throughout an individual's lifetime. While these mutations are often associated with microbial induction, early-life diet can independently affect IgA induction, its repertoire, and the diversity of its mutations.
In both germ-free and colonized mice subjected to different diets, dietary lipopolysaccharide contamination activated Toll-like receptor (TLR) 4 signaling, which in turn enhanced germinal center activity within the intestinal immune system. Interestingly, the impact of lipopolysaccharide on mucosal immune induction was observed only when it was delivered in colloidal liposomes, rather than in a dispersed solution. This suggests that the method of delivery plays a crucial role in its effectiveness.
Mooser et al. 2025 Immunity 58(7): 1778-1793…