meRfi®-GM
Secreted Immunoglobulin A (sIgA) / IgA
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Contents
Protective IgA plasma cells are produced in the presence of Treg-derived Transforming growth factor beta (TGF-beta) and epithelial cell-derived B cell activating factor of the tumor necrosis factor (TNF) family (BAFF) and a proliferation-inducing ligand (APRIL).
Most of the antibodies produced in the body are of the IgA class. The dominant cell population producing them are Plasmablast / Plasma cells, e.g., within the lamina propria of the [large](brain://QPZxhOY…
References (Sources)
- Dvander In vivo IgA coating of anaerobic bacteria in human faeces
- Know your enemy or Find your friend?—Induction of IgA at mucosal surfaces
- Lactobacillus rhamnosus GG Promotes Early B Lineage Development and IgA Production in the Lamina Propria in Piglets
- Microbiota-antibody interactions that regulate gut homeostasis
- Parallelism of intestinal secretory IgA shapes functional microbial fitness
- Selection of probiotic strains for human applications
- STING Promotes Intestinal IgA Production by Regulating Acetate-producing Bacteria to Maintain Host-microbiota Mutualism