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Experimentally, many different stem and progenitor populations have been shown to give rise to T cells, but the exact specificity and degree of lineage commitment of the cells that home to the thymus under physiological conditions is controversial and depends on the type of experimental model used
The establishment and maintenance of the blood system rely on self-renewing hematopoietic stem cells (HSCs) that generally reside in small numbers in the Bone marrow (BM) niche of adult mammals
The clas…