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Dectin-2 (CLEC6A) is a CD369 (C-Type lectin receptor (CLR)), a type II transmembrane protein that recognizes fungal alfa-mannans as a pattern recognition receptor. It has a carbohydrate recognition domain (CRD) that binds glycans in a Ca²⁺-dependent manner.
Malamud et al. 2024 EMBO Rep 25: 5239-5264
Dectin-2 associates non-covalently with the Fc receptor γ (FcRγ) chain, an ITAM-containing adaptor that enables downstream signaling via Syk kinase, [NFKB activation](brain://GMpzV2KgAk6TkzDhQzvzo…