Loading…
Cyclomodulins can disrupt key processes in eukaryotic cells, potentially leading to pathological changes and contributing to oncogenesis
Cyclomodulins can dysregulate the cell cycle, impact cell differentiation and apoptosis, and play a role in colonic oncogenesis
Some Escherichia coli strains produce toxins designated cyclomodulins (CMs) which interfere with the eukaryotic cell cycle of host cells, suggesting a possible link between these bacteria and cancers.
There are relatively few data available concerning the colonization of colon tumors by cyclomodulin- and genotoxic-producing E. coli.
Cyclomodulin-producing E. coli belonging mostly to B2 phylogroup colonize the colonic mucosa of patients with CRC.
see also:
Cancer microbiome / Tumor microbiota