meRfi®-GM
Adiposity / Obesity & Antibiotics
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Contents
Early-life antibiotic (ELA) exposure is associated with changes in obesity risk. The effects differ depending on the dosage and the sex of the subjects, as observed in both mouse experiments and human studies. When administered in low doses, antibiotics can enhance energy availability by modifying the gut microbiome. Conversely, high doses of antibiotics can deplete the gut microbiota, resulting in a short-term negative energy balance.
The majority of animal studies and meta-analyses of human studies on the association between antibiotics and subsequent development of Adiposity / Obesity are sugg…
References (Sources)
- Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences
- An energetic framework for gut microbiome-mediated obesity induced by early-life exposure to antibiotics
- Association of antibiotics in infancy with early childhood obesity
- Association of prenatal antibiotics with measures of infant adiposity and the gut microbiome
- Do Antibiotics Cause Obesity Through Long-term Alterations in the Gut Microbiome? A Review of Current Evidence
- Impaired Hypothalamic Microglial Activation in Offspring of Antibiotic-Treated Pregnant/Lactating Rats Is Attenuated by Prebiotic Oligofructose Co-Administration
- Infant antibiotic exposures and early-life body mass