Antibody-Drug-Conjugates (ADCs)

Most of the Antibody-Drug-Conjugates (ADCs), if not all, are immunotoxins but use whole antibodies and non-protein drugs

Antibody-Drug-Conjugates (ADCs) are a special class of therapeutics that have gained significant attention in the past decade. The idea behind ADCs is to be able to specifically deliver cytotoxic drugs to the tumor by leveraging antibody specificity, and in turn sparing normal cells of toxicity. ADCs consist of a monoclonal antibody conjugated, via a linker, to an extremely potent drug. So far, ADCs have been used specifically for the treatment of cancer. Antibodies used to formulate ADCs are specific for antigens overexpressed (or so…