Loading…
Please register to continue your trial period!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
T cells were found alongside Lewy bodies and dopaminergic neurons in postmortem Lewy body dementia (LBD) brains. These T cells exhibited upregulated expression of the C-X-C motif chemokine receptor 4 (CXCR4). Cerebrospinal fluid (CSF) protein levels of the CXCR4 ligand, C-X-C motif chemokine ligand 12 (CXCL12), were associated with neuroaxonal damage in Lewy body dementia (LBD). A phosphorylated alfa-synuclein epitope stimulated clonal expansion and upregulated [interleukin-17A expression by CD4+ T cells.](brain://dvP4DsnIIUWwUbolwjMOjQ/Th17E…