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The gut microbiota likely plays a role in the pathophysiology, as depicted in the "gut-muscle-bone axis" model. It shows the feedback between muscle and bone. Gut microbiota metabolites like SCFAs influence osteoblasts and muscle synthesis. Systemic inflammation exacerbates the breakdown. Myokines and osteokines regulate homeostasis. Gut microbiota manipulation through [diet](brain://NMz_R…