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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Caspase-8

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Introduction

Caspase-8 is a crucial enzyme in the process of apoptosis

Activation

The N-terminal FADD-like death effector domain of caspase-8 suggests that it may interact with the Fas-interacting protein FADD

Effects

Caspase-8 is the initiator caspase of extrinsic apoptosis and inhibits necroptosis mediated by RIPK3 and MLKL.
Fritsch et al. 2019 Nature 575: 683–687

It can directly cleave and activate caspase-3 or, alternatively, cleave Bid to trigger the mitochondrial pathway of apoptosis, linking…

References (Sources)

A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma
Mandruzzato et al., 1997
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3
Wieder et al., 2001
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Fritsch et al. 2019 Nature 575: 683–687
Caspase-8: regulating life and death
Tummers & Green 2017 Immunol Rev. 277(1): 76-89
Integration of innate immune signalling by caspase-8 cleavage of N4BP1
Gitlin et al. 2020
N4BP1 is dimerization-dependent linear ubiquitin reader regulating TNFR1 signalling through linear ubiquitin binding and Caspase-8-mediated processing
Kliza et al. 2021
Role for Caspase-8 in the Release of IL-1β and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection
Pandori et al. 2024 J Immunol 212(7): 1161-1171

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