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For Morbus Parkinson / Parkinson's Disease (PD) several animal studies suggested a positive effect of Fecal Microbiota Transplantation (FMT) , supported by some human case reports
FMT administration inhibits the CD284 (Toll-Like Receptor 4 (TLR-4)) / MYD88 / NFKB signaling pathway (From TNF receptor-associated Factor 6 (TRAF6) to NFKB) pathway in the substantia nigra and the colon, and there it suppresses the generation of pro-inflammatory molecules
Based on XXX - Fecal Microbiota Transplantation (FMT) & Morbus Parkinson / Parkinson's Disease (PD) Fresh FMT administered through colonoscopy is considered a safe and well-tolerated method for addressing mild-to-moderate Parkinson's Disease (PD). This procedure has been shown to effectively reduce both motor and non-motor symptoms, which in turn aids in defecation and enhances the overall quality of life for patients. The benefits of this treatment can last for at least 12 weeks, likely due to the positive changes it brings about in gut microbiota and fecal metabolites
Based on XXX - PRIM-DJ2727 & Morbus Parkinson / Parkinson's Disease (PD) , FMT treatment can lead to short-term improvements in motor function and constipation in PD patients. However, these effects are not maintained over a longer period. We hypothesize that to sustain the microbiome changes induced by FMT, a longer treatment duration and a concomitant modification in the patient’s diet may be necessary.
Fecal transplants may have alleviated some neurological symptoms in a Morbus Parkinson / Parkinson's Disease (PD) patient treated for constipation
see also:
Brain-Gut-Microbiome-Axis / Gut-Brain Axis & Morbus Parkinson / Parkinson's Disease (PD)
Fecal Microbiota Transplantation (FMT) & Neurodegeneration / Neurodegenerative Diseases (NDDs)
Fecal Microbiota Transplantation (FMT) & Preclinical/Clinical data
Gut Microbiota & Morbus Parkinson / Parkinson's Disease (PD)
Morbus Parkinson / Parkinson's Disease (PD) & Drugs/Treatments