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Nuclear receptors (Transcription factors)
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Key features:
Nuclear Receptors (Transcription Factors) have the ability to directly bind to DNA (= DNA-binding proteins) and regulate the expression of adjacent genes; they are intracellular receptors in contrast to membrane-bound receptors
Shown is the dimer of an intracellular receptor with an amino terminus (green), DNA binding domain (DNA-B.) and carboxyl terminus (LBD L).There are three important domains within the transcription factor: the DNA binding domain (DNA-B), the transactivation domain and the ligand binding domain (LBD L).
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References (Sources)
- Combinatorial roles of nuclear receptors in inflammation and immunity
- Interactions between bile salts, gut microbiota, and hepatic innate immunity
- Liver X receptor agonist inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways
- Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation
- PPAR ligand inhibits osteopontin gene expression through interference with binding of nuclear factor to A/T-rich sequence in THP-1 cells
- PPAR agonist suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes
- The coregulator exchange in transcriptional functions of nuclear receptors