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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Nuclear receptors (Transcription factors)

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Key features:
Nuclear Receptors (Transcription Factors) have the ability to directly bind to DNA (= DNA-binding proteins) and regulate the expression of adjacent genes; they are intracellular receptors in contrast to membrane-bound receptors

Nuclear Receptor (Transcription Factor)

Shown is the dimer of an intracellular receptor with an amino terminus (green), DNA binding domain (DNA-B.) and carboxyl terminus (LBD L).There are three important domains within the transcription factor: the DNA binding domain (DNA-B), the transactivation domain and the ligand binding domain (LBD L).

After…

References (Sources)

Combinatorial roles of nuclear receptors in inﬂammation and immunity
Glass et al. 2006 Nat. Rev. Immunol. 6: 44-55
Interactions between bile salts, gut microbiota, and hepatic innate immunity
Schubert et al. 2017 Immunological Reviews 279: 23-35
Review
Liver X receptor agonist inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways
Ogawa et al. 2005 Circ. Res. 95: 59-67
Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inﬂammation
Castrillo & Tontonoz 2004 Annu. Rev. Cell Dev. Biol. 20: 455-480
PPAR ligand inhibits osteopontin gene expression through interference with binding of nuclear factor to A/T-rich sequence in THP-1 cells
Oyama et al. 2002 Circ. Res. 90: 348-355
PPAR agonist suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes
Nakamachi et al. 2007 Diabetes 56: 1662-1670
The coregulator exchange in transcriptional functions of nuclear receptors
Glass et al. 2000 Genes Dev. 14: 121-141

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Nuclear receptor - Wikipedia