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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Omeprazole

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Omeprazole metabolites are generated by CYP2C19, CYP3A4, and glucuronosyltransferase (5-hydroxyomeprazole, 5-carboxyomeprazole, and 5-hydroxyomeprazole-O-glucuronide).
Jarmusch et al. 2020 Clin Transl Sci. 13: 972-84

Omeprazole sulfide is a reported bacterial metabolite and omeprazole sulfone is a reported CYP3A metabolite
Gu et al. 1992 Pharmacogenetics 2: 73-77
Chainuvati et al. 2003 Clin Pharmacol Ther 74: 437-447
Ma et al. 2006 Antimicrob Agents Chemother 50: 1130-1135

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Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1
Gu et al. 1992 Pharmacogenetics 2: 73-77
Combined phenotypic assessment of cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, xanthine oxidase activities with the "Cooperstown 5+1 cocktail"
Chainuvati et al. 2003 Clin Pharmacol Ther 74: 437-447
Enhanced characterization of drug metabolism and the influence of the intestinal microbiome: a pharmacokinetic, microbiome, and untargeted metabolomics study
Jarmusch et al. 2020 Clin Transl Sci. 13: 972-84
Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults
Ma et al. 2006 Antimicrob Agents Chemother 50: 1130-1135

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