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Characterizing the human virome requires a different approach because, unlike for cellular life, no gene or genomic region is homologous across all viruses. The current approach for studying these communities is to isolate virus-like particles (VLPs) using size fractionation and to sequence those using metagenomics (Caporaso et al., 2011a; Handley et al., 2012; Hurwitz et al., 2013; Reyes et al., 2010). Alternatively, viruses can be characterized using DNA microarrays (Jack et al., 2009; Palacios et al., 2007).
Goodrich et al. 2014 Cell 158(2): 250-262…