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In an intervention study in healthy volunteers, the use of metformin resulted in a change in >80 bacterial species compared with a control group receiving a placebo. Metformin promotes the growth of short-chain fatty acid producers in the gut, which contribute to its therapeutic benefits in improving insulin resistance and glucose homeostasis. The authors transplanted fecal samples from metformin-treated or placebo-treated donors into [germ-free mice](br…