meRfi®-GM
Janus Family Kinases (JAKs)
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Are enzymes of the JAK-STAT intracellular signaling pathway through which cytokines induce gene transcription in the nucleus. To do this, the enzymes (kinases) have to phosphorylate Signal Transducers and Activators of Transcription (STAT) Proteins (Signal transducer and activator of transcription 1 (STAT1), Signal transducer and activator of transcription 2 (STAT2), [Signal transducer and activator of transcription 3 (STAT3)](brain://dDEL-T…