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Brexanolone is a synthetic form of allopregnanolone, a metabolite of the hormone progesterone. It works by modulating and activating the gamma-aminobutyric acid (GABA) receptors in the brain, which are involved in regulating mood and anxiety. Brexanolone is a medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of postpartum depression (PPD). It is the first drug specifically designed and approved for this condition.
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