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Esophageal adenocarcinoma is the sixth most common cause of cancer death worldwide and Barrett's esophagus is the biggest risk factor.
The incidence of Esophageal Adenocarcinoma (EAC) / Esophageal cancer has increased in recent decades, and its 5-year survival rate is less than 20%. As a well-established precursor, patients with Barrett's esophagus (BE) have a persistent risk of progression to EAC. Many researchers have already identified some factors that may contribute to the development of BE and EAC, and the identified risks include [gastroesophageal reflux (GER)](brain://RAf2yfP3uEaEkcesXg_mIQ/Gastr…