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Although there are clear successes against mutation-targeting cancer drugs, our empirical analysis suggests that fewer than 16% of patients are eligible for these agents and fewer than 7% benefit from them.
To improve therapeutic outcomes for most Americans, progress in genome-specific approaches must accelerate and incorporate other approaches to improving patient outcomes, such as immunotherapy and cytotoxic therapies.
Each mutational process may involve components of DNA damage or modification, DNA repair and DNA replication (which may be normal or abnormal), and …