Lymphoid Tissue Inducer Cells (LTi cells)

Lymphoid Tissue Inducer (LTi) cells, a specialized subset of the innate lymphoid cell group 3 (ILC3s), are crucial for the development of lymphoid organs such as lymph nodes and Peyer's patches. These cells are distinguished by their unique gene expression profile and originate from a specific progenitor. LTi cells are not only integral to the formation of these lymphoid structures but also play vital roles in the activation and functionality of T and B cells. Due to their specialized functions and distinct characteristics, LTi cells are recognized as a separate lineage within the innate lymphoid family, distinctly different from other ILCs and conventional natural killer cells. This classification underscores their unique role and importance in the immune system.
Zhong et al. 2018 Cytokine Growth Factor Rev.…