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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Flagellin & Toll-like receptor 5 (TLR-5)

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Contents

Flagellin stimulates Toll-like receptor 5 (TLR-5) or evades Toll-like receptor 5 (TLR-5) by lack of recognition. There are silent flagellins that are weak TLR-5 agonists despite being recognized by TLR-5.
Clasen et al. 2023 Science Immunology 8(79): https://doi.org/10.1126/sciimmunol.abq7001

It has been reported that flagellin serves to activate phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway in the gut epithelium via a Toll-like receptor 5 (TLR-5)-dependent mechanism
Hayashi et al. 2001 Nature 410: 1099-103
Song et al. 2017 Sci Rep. 7: 40878

The rapid activation of th…

References (Sources)

A conserved TLR5 binding and activation hot spot on flagellin
Song et al. 2017 Sci Rep. 7: 40878
Flagellin-Stimulated Production of Interferon-β Promotes Anti-Flagellin IgG2c and IgA Responses
Kang et al. 2020b Mol Cells 43(3): 251-263
Host species adaptation of TLR5 signalling and flagellin recognition
Tahoun et al. 2017 Sci Rep. 7: 17677
Pathophysiological role of TLR-5 engagement by bacterial ﬂagellin in colonic inﬂammation
Rhee et al. 2005 Proc Natl Acad Sci USA 102: 13610-13615
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5
Clasen et al. 2023 Science Immunology 8(79): https://doi.org/10.1126/sciimmunol.abq7001
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi et al. 2001 Nature 410: 1099-103
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility
Smith et al. 2003 Nat Immunol. 4: 1247-1253

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https://doi.org/10.1126/sciimmunol.abq7001