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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Histone Deacetylase (HDAC) Inhibition & Propanoate Metabolism / Propionate / Propionic acid

Propionate is capable of HDAC inhibition
Arpaia et al. 2013 Nature 504: 451-455

Propanoate Metabolism / Propionate / Propionic acid blocks the differentiation of bone marrow stem cells into dendritic cells (DCs) via Histone Deacetylase (HDAC) Inhibition, thereby reducing undue inﬂammatory responses
Singh et al. 2010 Journal of Biological Chemistry. 285:27601-27608

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
Singh et al. 2010 Journal of Biological Chemistry. 285:27601-27608
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia et al. 2013 Nature 504: 451-455

5/29/2026