meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Enteric nervous system (ENS) & Gut microbiota
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Contents
Each microorganism can exert a different effect on the Enteric nervous system (ENS), including phenotypical neuronal changes or the induction of chemical transmitters that interact with ENS neurons.
Depletion of microbiota beget reductions in myenteric nerve fiber density, alterations in neurochemical coding, decreased excitability in intrinsic primary afferent neurons, defective EGC networks, changes in neurogenic colonic migrating motor complexes and protracted intestinal transit time, and these effects can be restored following recoloniza…
References (Sources)
- Abnormal absorptive colonic motor activity in germfree mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin
- Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility
- Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks
- Microbe-host interactions: Influence of the gut microbiota on the enteric nervous system
- Neuro-Immune Interactions at Barrier Surfaces
- Neuronal programming by microbiota regulates intestinal physiology
- The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse