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Tuft cells produce IL-25, which activates Group 2 ILCs (ILC2) to produce Interleukin-5 (IL-5), IL-9, and Interleukin-13 (IL-13). This circuit enhances type 2 inflammation and promotes tuft and goblet cell proliferation
Ting HA, von Moltke J. The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond. J Immunol. 2019 Mar 1;202(5):1321-1329
Feng, X., Flüchter, P., De Ten…