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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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CD223 (Lymphocyte Activation Gene 3 Protein) (LAG-3)

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Aliases: LAG3, CD223, lymphocyte activating 3

Lymphocyte activation gene-3 (LAG-3) is a member of the immunoglobulin superfamily. Engagement of LAG-3 by its ligands to trigger downstream signaling can inhibit immune responses and regulate the pathogenesis of many diseases, including cancer and inflammatory diseases.
Tian et al. 2022 Expert Review of Anticancer Therapy 22(3): 289-296…

References (Sources)

Adoptive immunotherapy for cancer: harnessing the T cell response
Restifo et al. 2012
Review
LAG-3 is a promising inhibitory immune checkpoint for antitumor immunotherapy
Tian et al. 2022 Expert Review of Anticancer Therapy 22(3): 289-296
Review

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12/16/2025

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CD223 (Lymphocyte Activation Gene 3 Protein) (LAG-3)

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