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Cellular effects of Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g) are context dependent and can be anti-tumorigenic or pro-tumorigenic (2).
In progressively growing tumors, the distinct timing of Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g) elaboration contributes to a state of adaptive resistance. This occurs due to the up-regulation of inhibitory molecules, such as programmed-death ligand 1 (PD-L1), on tumor cell targets and other host cells within the tumor microenvironment (1).
(1)
(2) Raza Zaidi…