Immunosenescence

Aging of the immune system is associated with reduced effectiveness of immunotherapy, and the pretreatment proportion of senescent T-cells would predict outcome. Immunosenescence markers may be potential biomarkers that could help guide cancer immunotherapy treatments
Rodriguez et al. 2022 Expert Review of Anticancer Therapy 22(9): 915-926

Immunosenescence means the decline of adaptive immunity with age.
Zhang et al. 2022g Front. Cell Dev. Biol. 10: 874940

Many responses of the innate immune system decline with age. However, there is also considerable evidence of age-related over-reactivity of the innate immune system.
Gomez et al. 2008 Exp Gerontol. 43:718-728
Kovacs et al. 2009 Trends Immunol. 30: 319-324
Panda et al. 2009 Trends Immunol. 30:325-333

see also:
Aging / Senescence & Inflammation / Inflammatory Diseases