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Aging of the immune system is associated with reduced effectiveness of immunotherapy, and the pretreatment proportion of senescent T-cells would predict outcome. Immunosenescence markers may be potential biomarkers that could help guide cancer immunotherapy treatments
Immunosenescence means the decline of adaptive immunity with age.
Many responses of the innate immune system decline with age. However, there is also considerable evidence of age-related over-reactivity of the innate immune system.
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