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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Sigma-1 Receptors (S1Rs)

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Contents

Sigma-1 Receptors (S1R), originally classified as an opioid receptor subtype, are being investigated for their potential in pain management, particularly for neuropathic pain
Ye et al. 2020 J Med Chem 63(24): 15187-15217
Raffa & Pergolizzi Jr. 2024 Cureus 16(5): e59882

Sigma-1 receptors (Sig-1R) are implicated in pain processing
Hornung et al. 2022 Mol Pain 18: 17448069211069255

S1Rs are widely expressed in the nervous system, including:

Neurons: Both principal neurons and interneurons express S1Rs
Liu et al. 2023k J Neurochem. 164(6): 764-785

Glial Cells: All types of glial cells, including astrocytes and microglia, express S1Rs
Liu et al. 2023k J Neurochem. 164(6): 764-785

Retina: S1Rs are found in various types of retinal neurons
Xu et al. 202…

References (Sources)

Advances with the discovery and development of novel sigma 1 receptor antagonists for the management of pain
Burns et al. 2023 Expert Opin Drug Discov 18(7): 693-705
Review
Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation
Wu et al. 2015 J Neurochem. 134(5): 904-14
Allosteric modulation of sigma-1 receptors elicits anti-seizure activities
Guo et al. 2015a Br J Pharmacol. 172(16): 4052-65
Sigma-1 receptor expression in a subpopulation of lumbar spinal cord microglia in response to peripheral nerve injury
Schonfeld et al. 2023 Sci Rep. 13(1): 14762
Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms
Xu et al. 2022c Int J Mol Sci. 23(14): 7572
Review
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases
Ye et al. 2020 J Med Chem 63(24): 15187-15217
Review
Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo
Liu et al. 2023k J Neurochem. 164(6): 764-785

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