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The agonist flagellin leads to dimerization. The two adapter molecules, TIR domain-containing adapter protein (TIRAP) and Myeloid Differentiation Primary Response 88 (MYD88) are activated. Receptor-associated MyD88 recruits Interleukin-1 receptor-associated kinase 4 (IRAK4) and Interleukin-1 receptor-associated kinase-1 (IRAK1), which then associate with [TNF receptor-associa…