Interleukin-18-binding protein (IL18BP)

Interleukin-18-binding protein (IL18BP) is a soluble protein that belongs to the immunoglobulin-like class of receptors. It has a high affinity for Interleukin-18 (IL-18), with a dissociation constant (Kd) of 399 pM. The protein's primary function is to neutralize Interleukin-18 (IL-18) activity by binding to it, thus acting as a natural inhibitor
Dinarello 2000 Ann Rheum Dis. 59(Suppl 1): i17-i20
Fauteux-Daniel et al. 2023 Front Immunol. 14: 1215364