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The integrity and stability of the genome is pervasively threatened by exogenous chemical, physical, and biological influences and endogenous challenges such as DNA replication errors, chromosome segregation defects, oxidative processes, and spontaneous hydrolytic reactions
The numerous genetic lesions caused by these extrinsic or intrinsic sources of damage include point mutations, deletions, translocations, telomere shortening, single and double-strand breaks, chromosomal rearrangements, defects in nuclear architecture, and disorders caused by the integration of genes into viruses or transposons.
Accordingly, organisms have ev…