meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Immunity & Vitamin D
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Contents
Vitamin D can also influence the abundance of several intracellular metabolites, supporting its role as an immunometabolic modulator
A comparison of various human macrophage phenotypes revealed differences in the amount of Vitamin D they produce
All macrophage subtypes express Cytochrome P450 family 24 subfamily A member 1 (Cyp24a1), allowing for degradation of Vitamin D through the 24-hydroxylase pathway
[Vitamin D](brain…
References (Sources)
- 1,25(OH)(2)D(3) promotes macrophage efferocytosis partly by upregulating ASAP2 transcription via the VDR-bound enhancer region and ASAP2 may affect antiviral immunity
- 1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus
- Polarization of human monocyte derived cells with vitamin D promotes control of Mycobacterium tuberculosis infection
- The effects of 1,25(OH)(2) D(3) treatment on immune responses and intracellular metabolic pathways of bone marrow-derived dendritic cells from lean and obese mice
- Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism
- Vitamin D counteracts lipid accumulation, augments free fatty acid-induced ABCA1 and CPT-1A expression while reducing CD36 and C/EBP β protein levels in monocyte-derived macrophages
- Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the inhibition of macrophage foam cell formation