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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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Immunity & Vitamin D

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Contents

Vitamin D can also inﬂuence the abundance of several intracellular metabolites, supporting its role as an immunometabolic modulator
Vrieling & Stienstra 2023 Trends in Immunology 44(3): 217

A comparison of various human macrophage phenotypes revealed differences in the amount of Vitamin D they produce
Vrieling & Stienstra 2023 Trends in Immunology 44(3): 217

All macrophage subtypes express Cytochrome P450 family 24 subfamily A member 1 (Cyp24a1), allowing for degradation of Vitamin D through the 24-hydroxylase pathway
Vrieling & Stienstra 2023 Trends in Immunology 44(3): 217

[Vitamin D](brain…

References (Sources)

1,25(OH)(2)D(3) promotes macrophage efferocytosis partly by upregulating ASAP2 transcription via the VDR-bound enhancer region and ASAP2 may affect antiviral immunity
Shi et al. 2022 Nutrients 14: 4935
1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus
Oh et al. 2009 Circulation 120: 687–698
Polarization of human monocyte derived cells with vitamin D promotes control of Mycobacterium tuberculosis infection
Rao Muvva et al. 2019 Front. Immunol. 10: 3157
The effects of 1,25(OH)(2) D(3) treatment on immune responses and intracellular metabolic pathways of bone marrow-derived dendritic cells from lean and obese mice
Cho et al. 2022 IUBMB Life 74: 378–390
Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism
Vanherwegen et al. 2019 J. Steroid Biochem. Mol. Biol. 187: 134-145
Vitamin D counteracts lipid accumulation, augments free fatty acid-induced ABCA1 and CPT-1A expression while reducing CD36 and C/EBP β protein levels in monocyte-derived macrophages
Marino et al. 2022 Biomedicines 10: 775
Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the inhibition of macrophage foam cell formation
Kumar et al. 2021 Autophagy 17: 2273–2289

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