Interleukin-22 Receptor (IL-22R)

Interleukin-22 receptors (IL-22R) play a crucial role in the body, primarily expressed in non-hematopoietic stromal cells. Research has shown that these receptors are localized in various tissues, including the intestinal mucosal barrier or mucus layer, hepatocytes, and pancreatic cells. This specific expression pattern suggests that IL-22R has specialized functions in these areas, contributing to the maintenance and repair of epithelial tissues and organs.

Several studies have contributed to our understanding of IL-22R distribution and function. For instance, Tachiiri et al. (2003), and subsequent research by Wolk et al. (2004), have documented the restricted expression of IL-22R to stromal cells. Further investigations by Zenewicz et al. (2007), Pickert et al. (2009), and Witte et al. (2010) have reinforced these findings, highlighting the receptor's role in immune modulation and tissue regeneration.

These collective insights, underscore the importance of IL-22R in health and disease, providing a foundation for potential therapeutic strategies targeting these receptors in various conditions associated with the tissues where they are expressed.

References:
Tachiiri et al. 2003 Genes Immun. 4: 153-159
Wolk et al. 2004 Immunity 21: 241-254
Zenewicz et al. 2007 Immunity 27: 647-659
Pickert et al. 2009 J. Exp. Med. 206: 1465-1472
Witte et al. 2010 Cytokine Growth Factor Rev. 21(5): 365-79